Abstract: OBJECTIVE To analyze the clinical value of hierarchical management mode in the prevention and control of infusion infection in outpatient department, so as to provide reference for improving the safety of outpatient infusion. METHODS Outpatient nurses with routine management from Jan. 2015 to Dec. 2015 were set as the routine management group, and the data related to infection prevention and control of outpatient infusion by the nosocomial infection quality control team (pass rate of finger colony sampling, pass rate of clothing, violation rate of infusion process operation, cases of disinfectant application error, pass rate of disinfection after use of care products, rate of nosocomial infection in patients after outpatient infusion) in 2015 were collected. From Jan. 2016 to Dec. 2016, outpatient nurses were managed with the hierarchical management mode, and set as the hierarchical management group. According to the qualifications, profession level, training and work experience, the outpatient nurses were divided into three levels, general, intermediate and advanced. Nurses of different levels were arranged to take charge of outpatient infusion with different extent of close relation to patients or care products having direct contact with patients. The data related to infection prevention and control of outpatient infusion by the nosocomial infection quality control team in 2016 was collected. The nosocomial infection quality control group had the same test items, frequency and judgment standard in the supervision of nosocomial infection prevention and control in outpatient infusionfor the two groups. The supervision results of the related indicators of infection prevention and control in outpatient infusion by the nosocomial infection quality control team and the incidence of nosocomial infection in outpatient infusion were compared between 2015 and 2016. RESULTS The pass rate of finger colony sampling, pass rate of clothing, violation rate of infusion process operation, cases of disinfectant application error, pass rate of disinfection after use of care products, and rate of nosocomial infection in patients after outpatient infusion in the routine management group were all significantly lower than those of the hierarchical management group (P<0.05). A total of 21 cases of nosocomial infection occurred in outpatient infusion patients in the conventional management group within one year, with an infection rate of 0.24%, whereas 9 cases of nosocomial infection occurred in outpatient infusion patients in the hierarchical management group within one year, with an infection rate of 0.10%. The infusion infection rate in patients of the hierarchical management group was significantly lower than that of the conventional management group (P<0.001). CONCLUSION The application of hierarchical management mode in management of outpatient nurses can effectively improve the supervision pass rate of infection prevention and control in outpatient infusion, thus effectively reducing the incidence of nosocomial infection in outpatient infusion, with a high clinical value. This management mode can be applied in hospitals with suitable conditions, so as to improve the safety of outpatient infusion.