Abstract: OBJECTIVE To investigate the correlation between upper respiratory tract infection in influenza-prone season and cardiovascular events in patients with coronary heart disease. METHODS The data of 640 patients with coronary heart disease (CHD) in the hospital from Dec. 2015 to Nov. 2017 were retrospectively observed. The cardiovascular events of CHD patients with upper respiratory tract infections in the season with high incidence of influenza were monitored. Demographic characteristics, general conditions, laboratory indicators, and clinical endpoints (cardiovascular events and all-cause mortality) within three months were studied. RESULTS In the influenza-prone season, there were 63 cases of coronary heart disease complicated with upper respiratory tract infection in the 640 patients, and the infection rate was 9.84%. Among the patients with CHD complicated by upper respiratory tract infection, 18 cases of cardiovascular events occurred, accounting for 28.57%, and there were 8 cases of all-cause death, was accounting for 12.70%. In contrast, 49 cases of cardiovascular events and 7 cases of all-cause death occurred in CHD patients without upper respiratory tract infection, accounting for 8.49% and 1.21%, respectively. The difference was significant (P<0.05).The case numbers of cardiovascular events and all-cause death on days 1 to 15 days were both higher than those on days 16 to 30 and days 31 to 90 (P<0.05). Logistic regression analysis showed that upper respiratory tract infection, heart rate of ≥100 beats/min, LVEF and C-reactive protein were the risk factors of cardiovascular events in patients with coronary heart disease during the season with high incidence of influenza. CONCLUSION Upper respiratory tract infections are closely related to cardiovascular events in patients with coronary heart disease in season with high incidence of influenza. Establishing a risk stratification and risk assessment system for post-respiratory infection in patients with coronary heart disease will help to improve the predictive ability of cardiovascular events in patients with coronary heart disease during upper respiratory tract infection in influenza-prone season, so as to provide some reference for clinical prevention and control.