Abstract: HT5"SSIn recent ten years, an increasing number of people have been paid attention to the researches on the influence of hospital environmental cleaning and disinfection on healthcare associated infection (HAI). However, the overall level of evidence in this field is generally low and the quality of papers is generally not high. This is because of some factors, such as clinical research design, environmental surface microbiological testing technology and the professional competence of cleaning staff. In January 2017, "Enhanced terminal room disinfection and acquisition and infection caused by multidrug-resistant organisms and Clostridium difficile (the Benefits of Enhanced Terminal Room Disinfection study): a cluster-randomised, multicentre, crossover study", written by more than ten American infection control experts, was published on the Lancet. It not only showed that the importance of terminal room disinfection, but also showed how to design and implement high-quality environmental intervention study. Thus, this article commented on this paper.