Abstract: OBJECTIVE To understand the distribution and drug resistance of Acinetobacter baumannii strains isolated from the ICU burn patients with infection in Jiangsu so as to provide guidance for clinical prevention and treatment of A.baumannii infection. METHODS By means of retrospective survey, the clinical data of patients who had A.baumannii infection and were treated in burn ICUs of 9 hospitals in Jiangsu from Jan 2013 to Dec 2015 were analyzed.The wound secretions, urine, sputum and blood specimens were collected from the patients so as to conduct bacterial culture, and the drug resistance of the strains was observed. RESULTS A total of 250 strains of A.baumannii were isolated from various types of submitted specimens of 182 patients with A.baumannii infection, 105 (42.00%) of which were isolated from wound secretions, and 83 (33.20%) were isolated from sputum specimens.The baseline clinical data of the patients showed that the proportions of male patients, the patients aged less than 65 years old and the patients with the length of hospital stay no less than 7 days were high, while the proportions of the patients who were treated with broad spectrum antibiotics, had coma, were treated with mechanical ventilation and hormones were relatively low.The result of drug susceptibility testing indicated that the drug resistance rates of the A.baumannii strains to aminoglycosides and some compound enzyme inhibitors were more than 52.40%, the drug resistance rate to cephalosporins was more than 42.00%, the drug resistance rate to carbapenems was as high as 43.60%, and the drug resistance rate to levofloxacin was the lowest (30.00%). CONCLUSION The isolation rate of A.baumannii strains is high among the opportunistic pathogens isolated from the burn ICUs, the strains are mainly isolated from the wound secretions, which is associated with the large area of burns, length of burn ICU stay and use of broad spectrum antibiotics.The strains are highly resistant to the commonly used antibiotics.It is necessary to reasonably use antibiotics based on the species and drug resistance of the pathogens and improve the clinical therapeutic effect so as to reduce the incidence of A.baumannii infection in the burn ICUs.