Abstract: OBJECTIVE To explore the clinical and value of multidisciplinary team in prevention and control of multidrug-resistant organism (MDROs) infections in ICU. METHODS Totally 758 patients who were treated in ICU from Jan 2016 to Dec 2016 were chosen as the control group, and 827 patients who were treated from Jan 2017 to Dec 2017 were set as the intervention group.The conventional prevention and control measures were taken in the control group, and the multidisciplinary team model was carried out in the intervention group.The incidence of MDRO infections, status of implementation of prevention and control measures and treatment outcomes were observed and compared between the two groups of patients. RESULTS Totally 75 of 827 patients had infections in the intervention group, with the infection rate 9.07%, and 93 case-times of patients had infections, with the case-time infection rate 11.25%.Totally 96 of 758 patients had infections in the control group, with the infection rate 12.66%, and 116 case-times of patients had infections, with the case-time infection rate 15.30%; there were significant differences in the infection rate and the case-time infection rate between the two groups of patients (χ²=5.314,5.689; P=0.023,0.018).The incidence rate of MDROs infections was 4.23%(35/827) in the intervention group, significantly lower than 8.71%(66/758) in the control group(χ²=13.275,P＜0.001).The compliance rates of the prevention and control measures, wearing gloves and isolation gowns, dedicated use of articles and transferring notification as well as the awareness rates of doctors, nurses and nursing workers were significantly increased after the intervention measures were taken(P＜0.05).The length of hospital stay of the patients with MDROs infection was significantly shorter in the intervention group than in the control group, and the hospitalization cost of the patients with MDROs infection was significantly less in the intervention group than in the control group (P＜0.001).The treatment outcomes of the patients with MDROs infection were better in the intervention group than in the control group. CONCLUSION The multidisciplinary team model may achieve remarkable effect on prevention and control of the MDRO infections in the ICU, and it is worthy to be promoted in the hospital.