Abstract: The aim of this paper was to discuss whether contaminated medical instruments should be pretreated at the points-of-use. The two groups of academics with different views discussed about whether contaminated medical instruments should be pretreated at the points-of-use, and the debate included five stages, making the argument, summing up the argument, attack, freedom debate, and summing up, with the requests of clear and adequate argument, in addition to citing normative and evidence-based literature to support the argument. Some academics believed that the pretreatment of contaminated medical instruments at the points-of-use could ensure the cleaning quality and sterilization effect of the medical instruments to the maximum extent. As a special instrument, immediate pretreatment of endoscopy beside the bed unit is an example of the pretreatment of contaminated medical instruments at the points-of-use. Other academics believed that the pretreatment of contaminated medical instruments have requirements of certain facilities, but the majority of the points-of-use lack the conditions. In such case, the risks of environmental pollution and the occupational exposure of staff would increase. How to cooperate efficiently between the points-of-use and the disinfection supply center on the pretreatment of contaminated medical instruments is the key issue to guarantee the cleaning quality and sterilization effect of the multiplexing instruments.