Abstract: OBJECTIVE To retrospectively analyze the utilization rates of antibiotics and prevalence rates of nosocomial infections in hospitalized patients from 2010 to 2016, explore the effect of special stewardship program on clinical use of antibacterial drugs so as to provide data support and scientific basis for reasonable use of antibiotics and development of prevention and control measures. METHODS Comprehensive management measures were taken, the management of use of antibiotics was strengthened, the data in relating to the use of antibiotics and prevalence rates of nosocomial infections were extracted from the hospital in 2010-2016, and the descriptive analysis and comparative study were conducted for the prevalence rates of nosocomial infections and use of antibiotics at different time points. RESULTS The number of cases of hospitalized patients showed a remarkable increase in 2010-2016, the mean prevalence rate of nosocomial infection was 1.99%-2.62%, the yearly average prevalence rate of nosocomial infection was 2.26% in the 7 years, the yearly average case-time prevalence rate was 2.72%-3.18%, the yearly average prevalence rate of nosocomial infection was 2.96%, with the fluctuation less significant. The utilization rates of antibiotics of the hospitalized patients showed remarkable decrease, decreasing from 53.32% in 2010 and 53.39% in 2011 to 35.03% in 2015 and 35.15% in 2016. Meanwhile, the utilization rates of restricted, special antibiotics dropped significantly, indicating that the special stewardship program for clinical use of antibiotics has achieved remarkable effect. CONCLUSION The 7 consecutive years of surveillance data showed that the utilization rates of antibiotics of the hospitalized patients were remarkably decreased in the general hospital through comprehensive management measures and reasonable use of antibiotics, and reasonable use of antibiotics was strengthened, in the meantime, the prevalence rates of nosocomial infections showed steady level, indicating that the comprehensive management of antibiotics had achieved remarkable effect but still needed to establish a long-term effect mechanism and the reasonable use of antibiotics needs to be further improved.