Abstract: OBJECTIVE To explore the correlation between nuchal translucency thickness (NT) and development of fetuses with intrauterine TORCH infection. METHODS A total of 152 singleton pregnant women and fetuses who received prenatal examination in the hospital from Jan 2015 to Jan 2017 were recruited as the study objects and divided into the neck hygroma group with 12 cases, the 2.5-2.9 mm group with 43 cases, the 3.0-3.4 mm group with 37 cases, the 3.5-4.4 mm group, and the no less than 4.5 mm group with 29 cases according to the fetal NI value. The chromosome aneuploid risk value of the pregnant women was calculated, the number of cases of abnormal fetuses and constituent ratios were taken for statistics, and the pregnancy outcomes of the pregnant women were recorded. RESULTS Of the 152 fetuses, 40 had chromosomal abnormalities, accounting for 26.32%. The constituent ratios of the fetuses with karyotype 45, X, 18-trisomy and 21-trisomy syndrome were high both among the children with chromosomal abnormalities and among all of the fetuses (P＜0.05). The incidence rates of structural malformation, cardiac structural malformation and chromosomal abnormalities were high in the neck hygroma group, the 3.5-4.4 mm group, and the no less than 4.5 mm group (P<0.05). Totally 56 pregnant women had the labor induction, 47 of whom had chromosomal abnormalities or severe structural malformation, 7 cases were severe alpha thalassemia, and 2 cases were social factors. The incidence of labor induction was high in the neck hygroma group, the the 3.5-4.4 mm group, and the no less than 4.5 mm group; the incidence of stillbirth was high in the neck hygroma group and the no less than 4.5 mm group (P＜0.05). CONCLUSION The NT value is associated with the abnormal development of fetuses such as the fetal cardiac structure abnormality and chromosome abnormality, and the incidence of abnormal development of fetuses with fetal cardiac structure abnormality and chromosome abnormality is increased with the NT value.