Abstract: OBJECTIVE To understand the correlation between the drug resistance of Acinetobacter baumannii strains isolated from a geriatric hospital in 2011-2016 and the use intensity of antibiotics so as to provide guidance for reasonable clinical use of antibiotics. METHODS By means of retrospective survey, the drug resistance rates of the A.baumannii strains isolated from the patients who were hospitalized from 2011 to 2016 and the use intensity of antibiotics were summarized, the data were statistically analyzed by using SPSS20.0 software, and the Spearman correlation analysis was performed for the correlation between the drug resistance and the use intensity of antibiotics. RESULTS The result of drug susceptibility testing for the clinical isolates of A.baumannii indicated that the drug resistance rates of the A.baumannii strains to most of the antibiotics were increased year by year in 2011-2016, the drug resistance rates to cefepime and ceftazidime showed upward trends, increasing from 72.36% and 76.02% in 2011 to 81.72% and 83.60% in 2016 (χ²=16.460, 24.180,P＜0.05); the drug resistance rate to imipenem was 72.13% in 2011, 77.42% in 2016 (χ²=6.010,P＜0.05); the drug resistance rate to levofloxacin was increased from 70.15% in 2011 to 79.57% in 2016 (χ²=11.88,P＜0.05); the drug resistance rate to compound sulfamethoxazole was increased from 22.34% in 2011 to 56.99% in 2016 (χ²=232.340,P＜0.01); the drug resistance rate to cefoperazone-sulbactam did not change significantly.The use intensities of penicillins and cephalosporins were decreased year by year, the use intensities of carbapenems and quinolones were increased year by year, and the use intensities of other antibiotics did not change significantly.The drug resistance rate of the A.baumannii strains to cefepime was associated with the use intensity of cephalosporins, especially the fourth generation of cephalosporins (r=0.829, 0.928,P＜0.05), and was associated with the use intensity of carbapenems (r=0.943,P＜0.05).The drug resistance rate of the A.baumanni strains to levofloxacin was associated with the use intensity of quinolones (r=0.829,P＜0.05).The drug resistance rate to imipenem was associated with the use intensity of carbapenems (r=0.851,P＜0.05) and was associated with the use intensity of fourth generation cephalosporin (r=0.841,P＜0.05). CONCLUSION The drug resistance rate of the A.baumannii strains shows an upward trend in the hospital, the increase of the drug resistance rate is closely associated with the excessive use of antibiotics.Quinolones are not suitable for treatment of the A.baumannii infection.The indications for use of carbapenems must be followed, and cefoperazone-sulbactam can be used for combined drug therapy.