Abstract:
OBJECTIVE To systematically review the related factors for death of the patients with
Acinetobacter baumannii bloodstream infection. METHODS The databases including PubMed, CNKI, CBM, WanFang and VIP were electronically searched for related literature that were published from the establishment of the databases to Jan 2018, the eligible literatures were screened out by 2 researchers according to the inclusion and exclusion criteria, the data were extracted, the quality was evaluated, and the meta-analysis was performed with the use of RevMan5.3 and Stata14.0 software. RESULTS A total of 39 literatures were included.The meta-analysis showed that the related factors for death of the patients with
A.baumannii bloodstream infection included the septic shock (
OR=5.17,95%
CI: 3.06-8.73), MDR-ABB(
OR=6.76,95%
CI: 2.85-16.03), Pitt bacteremia score(
OR=1.74,95%
CI: 1.21-2.52), CR-ABB(
OR=3.08,95%
CI: 1.35-7.04), ICU stay(
OR=2.57,95%
CI: 1.22-5.43), use of ventilator(
OR=3.94,95%
CI: 2.80-5.54), APACHE II score(
OR=1.19,95%
CI: 1.15-1.23), neutrophil deficiency(
OR=5.48,95%
CI: 2.95-10.20), immunosuppression (
OR=4.60,95%
CI: 2.17-9.76), malignant tumor(
OR=4.12,95%
CI: 2.81-6.03), inappropriate antibiotic therapy(
OR=4.73,95%
CI: 3.16-7.08), SOFA score(
OR=1.35,95%
CI: 1.24-1.46) and respiratory tract ABB(
OR=3.30,95%
CI: 2.17-5.03). CONCLUSIONS The mortality of the patients with
A.baumannii bloodstream infection is closely associated with the 13 factors such as septic shock, MDR-ABB, Pitt bacteremia score, CR-ABB, ICU stay, use of ventilator, APACHE II score, neutrophil deficiency, immunosuppression, malignant tumor, inappropriate antibiotic therapy, SOFA score and respiratory tract bloodstream infection.It is of positive role to identify the controllable factors and take intervention measures so as to reduce the mortality rate of the patients with
A.baumannii bloodstream infection.