Abstract: OBJECTIVE To implement the continuous quality improvement and evaluate the effect so as to reduce the incidence of bloodborne occupational exposure among health care workers. METHODS By means of PDCA, the current status of bloodborne occupational exposure among the health care workers was analyzed, the improvement measures were carried out, and rigid examination was conducted.The qualified rate of assessment of quality of occupational protection, incidence of bloodborne occupational exposure and incidence of bloodborne occupational exposure in different positions were observed and compared before and after the PDCA was carried out. RESULTS The qualified rates of the health care workers' awareness of standard prevention concepts and reporting procedures, allocation of occupational protection box and isolation measures were significantly higher after the PDCA was carried out than before it was carried out(P＜0.05).Totally 278 case-times of health care workers had the bloodborne occupational exposure after the PDCA was carried out, the incidence of the exposure was 2.91/100FTE, significantly lower than that before the PDCA was carried out (χ²=6.774,P=0.009).The nurses were the predominant health care workers who had the bloodborne occupational exposure, accounting for 39.21% (231/589), followed by the students 30.73%(184/589). CONCLUSION It is an effective way to carry out the PDCA, take the prevention measures as first priority and focus on the process of management so as to reduce the incidence of the bloodborne occupational exposure and ensure the occupational safety of the health care workers.