Abstract: OBJECTIVE To explore the clinical characteristics and related factors for postoperative nosocomial infections in patients undergoing interventional procedures so as to provide guidance for control of the infections due to the interventional procedures. METHODS By means of prospective cohort study, the patients who received interventional procedures in intervention department of a three-A hospital from Jan 2017 to Dec 2017 were recruited as the study objects.The incidence of postoperative nosocomial infections, infection sites and pathogens causing the infections were observed, and the univariate chi-square test and multivariate logistic regression analysis were performed. RESULTS Of totally 1308 hospitalized patients who received the interventional procedures, 63 (65 case-times) patients had postoperative nosocomial infections, with the infection rate 4.82%, the case-time infection rate 4.97%.The abdominal (pelvic) cavity, lower respiratory tract and catheter indwelling site were the major infection sites; the patients with abdominal (pelvic) infection were dominant, accounting for 47.69%.Totally 31 strains of pathogens were isolated from the 63 patients, 14 (45.16%) of which were gram-positive bacteria, 16 (51.61%) were gram-negative bacteria, and 1 (3.23%) was fungus.The univariate analysis showed that malignant tumor, number of times of surgery, types of surgery and postoperative catheter indwelling were the related factors for the nosocomial infections.The multivariate logistic regression analysis indicated that the postoperative catheter indwelling, types of surgery and malignant tumor were the independent related factors for the infections. CONCLUSION There are a variety of influencing factors for the postoperative nosocomial infection in the patients undergoing the interventional procedures.It is necessary to strengthen the monitoring of the patients and take targeted and comprehensive prevention measures so as to prevent the infections.