Abstract: OBJECTIVE To investigate the related factors for postoperative surgical site infections in patients with endometrial carcinoma so as to provide guidance for clinical treatment. METHODS The clinical data of 587 patients with endometrial carcinoma who received surgical procedures in Third Affiliated Hospital of Guizhou Medical University from Feb 2012 to Jun 2018 were retrospectively analyzed, and the univariate analysis and multivariate logistic regression analysis were performed for the related factors for the surgical site infections. RESULTS Of the 587 patients with endometrial carcinoma, 65 had surgical site infections, with the infection rate 11.07%.The multivariate logistic regression analysis indicated that the laparoscopy (OR=2.167, 95%CI:1.099~4.271), chemotherapy (OR=3.495, 95%CI:1.811~6.747 ), blood glucose no less than 10mmol/L(OR=6.324, 95%CI:2.478~16.140), FIGO stage-ⅢⅣ(OR=2.050, 95%CI:1.131~3.715) and time of drainage tube indwelling no less than 7 days (OR=2.640, 95%CI:1.404~4.964)were the independent influencing factors for the surgical site infections in the patients with endometrial carcinoma (P＜0.05). CONCLUSION It is necessary to effectively control the blood glucose for the patients with endometrial carcinoma who intend to receive surgical procedures, try to carry out minimally invasive surgery, evaluate the drainage and removal of tubes, shorten the draining indwelling time and put forward reasonable chemotherapy program.