Abstract: OBJECTIVE To explore the extension of hospitalization duration and increase of hospitalization cost due to different sites of nosocomial infections in the hypertensive cerebral hemorrhage patients receiving surgical procedures so as to provide guidance for development of related policies. METHODS The clinical data of 272 patients with hypertensive cerebral hemorrhage who received surgical procedures in wards of neurosurgery department of a three-a hospital from 2015 to 2016 were retrospectively analyzed, the patients who had nosocomial infections were assigned as the infection group, the patients were screened out in a 1:1 conditional matching ratio and were set as the control group.The mean hospitalization cost and hospitalization duration were defined as median, and the economic loss was compared by using rank sum test. RESULTS Of the 272 hypertensive cerebral hemorrhage patients undergoing the surgical procedures, the incidence rate of nosocomial infection was 20.96%(57/272), the case-time infection rate was 25.37%(69/272); the patients with lower respiratory tract infection were dominant, accounting for 59.42%(41/69).The different sites of infection led to different direct economic losses (P＜0.05).The direct economic loss was the greatest in the patients with lower respiratory tract infection.For the different age groups of patients, there were significant differences in the increase of hospitalization cost and the extension of hospitalization duration between the infection group and the control group (P＜0.05). CONCLUSION The lower respiratory tract infection in the patients with hypertensive cerebral hemorrhage may lead to the increase of hospitalization cost and the extension of hospitalization duration, with the direct economic loss greatest.It is necessary to effectively control the lower respiratory tract infections.