Abstract: OBJECTIVE To explore the related factors for postoperative incision infections in patients undergoing spinal surgery and observe the effect of comprehensive interventions on reduction of incidence of the postoperative incision infections. METHODS Totally 1109 patients who underwent the spinal surgery in the hospital from May 2016 to May 2017 were assigned as the control group, the incidence of the postoperative incision infections and the related factors were analyzed, the intervention measures were put forward.Totally 1273 patients who received the spinal surgery in the hospital from Jun 2017 to Jun 2018 were chosen as the experimental group, and the intervention measures were carried out.The effects of the intervention measures, incidence of surgical incision infection, average length of hospital stay and hospitalization costs were observed. RESULTS The major related factors for the postoperative incision infections in the patients undergoing the spinal surgery included preoperative skin cleaning, internal fixation material or gelatin sponge and drainage tube.The rate of preoperative implementation of chlorhexidine rubbing bath, rate of implementation of self-purification time no less than 30 min and rate of implementation of removal of drainage tube within 24 hours were increased in the experimental group, while the utilization rates of intraoperative SPR, gelatin sponge and rate of unreasonable prophylactic use of antibiotics were significantly decreased (P＜0.05).The incidence rate of postoperative incision infection of the experimental group was 0.79%(10/1273), significantly lower than 2.07%(23/1109) of the control group(χ²=7.201,P=0.007).The length of hospital stay of the experimental group was (13.01±8.57)days, significantly shorter than (14.87±10.45)days of the control group; the hospitalization cost of the experimental group was (2.37±1.27)ten thousand yuan, significantly less than (2.94±1.64)ten thousand yuan of the control group(χ²=4.764,9.706,P＜0.001). CONCLUSION It is an effective way to take targeted intervention measures according to the related factors for the postoperative incision infections in the patients undergoing the spinal surgery so as to reduce the incidence of postoperative incision infections, shorten the length of hospital stay and cut the hospitalization cost.