Abstract: OBJECTIVE To analyze the clinical data of lung sarcoidosis and improve the ability to differentiate from tuberculosis, so as to reduce misdiagnosis and improve the diagnosis and treatment of sarcoidosis. METHODS A total of 40 patients with sarcoidosis diagnosed with pathology who were misdiagnosed of pulmonary tuberculosis in other hospital admitted to PLA General Hospital from Jan. 1, 2016 to Dec. 31, 2016 were analyzed from general data, clinical features, laboratory tests, imaging data and treatment and followed-up 1 year to observe their prognosis. RESULTS The study showed that the ratio of males to females was 1: 2.08. The patients aged 45-60 years old were 17cases and that of patients aged 60-76 years old were 11 cases. The pathological feature of sarcoidosis was non keratoid granuloma. Among 40 cases of patients, most showed mediastinal or hilar lymph node enlargement and multiple nodules by CT, and a majority of patients mixed a variety of images. The overall abnormal rate of lung function increased with the increase of staging, and there was a significantly difference in the abnormal rate of pulmonary function between stages (P=0.011). The study found that lung involvement in patients with sarcoidosis was more common, the major symptoms were cough, chest tightness and shortness of breath, fever and chest pain. The abnormal rate of laboratory-related indicators of patients showed ACE (57.50%) and ESR (35.00%). The study showed that the abnormal rate which used N/L=2.25 as the cut-off value was 72.50%. Improvement rate of hormone therapy was 91.70%. CONCLUSION Sarcoidosis need to be analyzed from the general data, clinical features, laboratory tests, imaging data and treatment prognosis, and diagnosed with pathology.