Abstract: OBJECTIVE To analyze the clinical value of compound gargle solution chlorhexidine giuconatie, cetylpyridinium chloride buccal tablets and Xipayi mouth rinse in the prevention of early infection after implant implantation.METHODS A total of 200 patients undergoing elective implantation during the period from Feb. 2017 to Jan. 2018 were randomly divided into four groups（A, B, C and D）, with 50 cases in each group. Group A rinsed the mouth with normal saline for 7 days after surgery while group B, C and D rinsed the mouth with compound gargle solution chlorhexidine giuconatie, cetylpyridinium chloride buccal tablets and Xipayi mouth rinse for 7 days, respectively. Early bacterial culture in each group after surgery was analyzed. The degree of oral pain was assessed by visual analogue scale（VAS） on the next day after surgery. The periodontal index and wound healing in each group were measured on day 7 after surgery. The effects of implantation in each group were evaluated at 4 weeks after surgery. The gingival crevicular fluid around the implant was collected before surgery and at 4 weeks after surgery to determine the levels of osteopontin（OPN） and alkaline phosphatase（ALP）.RESULTS There were significant differences in subgingival obligate anaerobes counts and postoperative VAS scores among the four groups（P＜0.05）. The obligate anaerobes counts in group B, C and D were significantly lower than that in group A（P＜0.05）. The proportions of VAS score-painless（34.00%, 40.00%, 54.00%） were significantly higher than those in group A（0）（P＜0.05）. There were significant differences in modified plaque index（mPLI） among the four groups at 1 week after surgery（P＜0.001）. The mPLI in group B, C or D （0.61±0.51）,（0.60±0.48）,（0.58±0.51） was significantly lower than that in group A （1.26±0.42）（P＜0.05）. There were significant differences in wound healing grade among the four groups at 1 week after surgery. The wound healing effect of group B, C and D was significantly better than that of group A（P＜0.05）. The proportions of good wound healing in group B, C or D（74.00%, 80.00%, 86.00%） was significantly higher than that in group A（32.00%）（P＜0.05）. There were significant differences in OPN and ALP among the four groups at 4 weeks after surgery（P＜0.05）, and the above indexes in group B （0.51±0.09）,（226.53±18.71） pg/ml, C（0.52±0.08）,（220.72±20.51） pg/ml and D（0.51±0.10）,（221.92±21.53） pg/ml were significantly lower than those in group A （0.79±0.04）,（405.23±42.53）（P＜0.05）. There was no significant difference in the success rates of implantation among the four groups（98.00%, 100.00%, 100.00%, 100.00%）（P=0.392）.CONCLUSION Compound gargle solution chlorhexidine giuconatie, cetylpyridinium chloride buccal tablets and Xipayi mouth rinse can all effectively prevent early infection after implant implantation, which helps to relieve postoperative oral pain, promote wound healing, improve periodontal index and relieve inflammation around the implant.