Abstract: OBJECTIVE To explore the effect of comprehensive first aid scheme on children with high febrile seizures caused by upper respiratory tract infection.METHODS Totally 82 children with febrile convulsions caused by upper respiratory tract infection in Fujian Maternal and Child Health Hospital from May. 2017 to Sep. 2018 were randomly divided into control group（n=41） and study group（n=41）. The control group was treated with routine first-aid methods, and the study group was treated with the first-aid treatment on the basis of the control group. The convulsion time, fever time and hospitalization time of the two groups were compared. The two groups were followed up for half a year and the recurrence of the two groups were compared. The therapeutic effects of the two groups were observed and compared.RESULTS The convulsion disappearance time, fever time and hospitalization time in the study group were（3.67±3.14） days,（28.01±19.23） h, and（5.43±2.25） days, respectively, which were lower than those in the control group（P＜0.05）. The recurrence rate in the study group was 2.44%（1/41）, which was shorter than that in the control group(36.59%（15/41）（P=0.025）. The efficacy of the study group was better than that of the control group（P=0.021）.CONCLUSION The comprehensive first aid scheme can provide effecient first aid guidance for clinical medical staff and help clinical staff to quickly treatment. The comprehensive first aid scheme can effectively improve the clinical symptoms of children with high febrile seizures caused by upper respiratory tract infection, improve the curative effect, and reduce the recurrence rate of children.