Abstract: OBJECTIVE To explore the influencing factors for postoperative incision infection in the colorectal cancer patients undergoing transumbilical minimally invasive laparoscopic surgery and conventional laparoscopic radical resection and observe the influence on inflammatory factors. METHODS A total of 74 patients with colorectal cancer who were treated in Tianjin Occupational Disease Prevention and Treatment Institute were enrolled in the study, the control group was treated with conventional laparoscopic radical resection, and the study group was treated with transumbilical minimally invasive laparoscopic surgery for radical resection. The incidence of postoperative incision infection and the influencing factors were observed, and the levels of inflammatory factors, intraoperative and postoperative indexes were compared between the two groups of patients. RESULTS The incidence rate of postoperative incision infection was 22.97%(17/74). The influencing factors for the infection included operation duration, body mass index, perioperative hypothermia, intraoperative blood transfusion, conventional laparoscope, surgical sites, preoperative hypoalbuminemia and diabetes mellitus. The levels of inflammatory factors of the study group were significantly lower than those of the control group before the surgery (P<0.05). There was no significant difference in the operation duration. The intraoperative blood loss volume of the study group was significantly less than that of the control group; the time of recovery of intestinal function, time of off-bed activity and length of postoperative hospital stay were significantly shorter in the study group than in the control group (P<0.05). CONCLUSION The operation duration, BMI, perioperative body temperature, intraoperative blood transfusion, surgery mode, surgical site, preoperative hypoalbuminemia and diabetes mellitus are the influencing factors for the postoperative incision infection in the colorectal cancer patients. The intraoperative blood loss volume, time of recovery of intestinal function, time of off-bed activity and length of postoperative hospital stay of the patients undergoing the transumbilical minimally invasive laparoscopic surgery are less than those of the patients undergoing the conventional laparoscopic radical resection, and the transumbilical minimally invasive laparoscopic surgery may facilitate the postoperative recovery.