Abstract: OBJECTIVE To comprehensively evaluate the influencing factors of bloodstream infection caused by carbapenem-resistant Acinetobacter baumannii (CRAB), so as to provide evidence for the prevention and control of infection. METHODS The PubMed, Embase, Chinese biomedical literature database (CBM), Wanfang, Weipu and CNKI databases were searched by computer, supplemented by Internet retrieval, and the full text of the initially selected literatures were subjected to manual retrieval.The related literatures about the factors influencing the bloodstream infection caused by carbapenem-resistant A baumannii were collected, and the clinical data that met the standard were selected.Two researchers screened the literature according to the inclusion and exclusion criteria and extracted the data. Quality evaluation was conducted by referring to the quality evaluation standard of Newcastle- velocity Scale, and Meta analysis was conducted using CMA software. RESULTS Totally 15 articles were included in this study. The total of 1893 cases were analyzed for 15 influencing factors, and 11 factors showed significant differences, including deep vein catheterization (OR=2.581, 95%CI=1.630~4.086), airway open (OR=3.370, 95%CI=2.015~5.637), underlying diseases (OR=2.587, 95%CI=1.711~3.913), use of two or more kinds of antimicrobial agents (OR=3.014, 95%CI＝1.636~5.550), indwelling catheters (OR=2.656, 95%CI=1.382~5.014), use of carbapenems (OR=2.683, 95%CI=2.017~3.570), nasal gastrointestinal tube (OR=2.335, 95%CI=1.220 ~4.467), parenteral nutrition (OR=2.835, 95%CI=1.648~4.876), primary infection focus (OR=4.219). 95%CI=1.274~13.974), APACHEII score greater than or equal to 22 (OR=8.332, 95%CI=2.836~24.481), and ICU entry rate greater than or equal to 2 weeks (OR=2.835, 95%CI=1.391~5.776). CONCLUSION We should take measures according to the risk factors for CRAB-associated bloodstream infection, so as to reduce and prevent the occurrence of CRAB-associated bloodstream infection.