Abstract: OBJECTIVE To investigate the characteristics and risk factors of nosocomial infection in geriatrics department, summarize and take corresponding control measures to effectively reduce the incidence of nosocomial infections. METHODS A total of 1408 elderly hospitalized patients aged 60 years and older, hospitalized for >48 hours, and with complete medical records from Jan. 2014 to Nov. 2018 were monitored and analyzed. Among them, 212 cases of nosocomial infection occurred. Logistic regression analysis was used to assess the association of various risk factors with nosocomial infections. RESULTS The incidence of nosocomial infection in elderly patients of geriatrics department was 15.06%. The lower respiratory tract was the main site of infection, followed by the urinary system. The main pathogens of nosocomial infections were gram-negative bacteria, followed by gram-positive bacteria and fungi. The use rate of antibacterial drugs was 29.40%.The pre-use inspection rate was 40.82%. Logistic regression analysis showed that the risk of nosocomial infection was higher in men than in women. Compared with patients aged 60-69 years old, the risk of nosocomial infection increased for patients aged 80 to 89 years old and ≥90 years old (P<0.05). Compared with hospital stay ≤7 d, the risk of nosocomial infection was significantly increased for patients with hospital days between 15 and 30 days and ≥31 days (P<0.05). Central venous cannula, urinary cannulation, and use of ventilator increased the risk of nosocomial infection (P<0.001). CONCLUSION The elderly patients over 80 years old in geriatrics department are extremely at high risk of nosocomial infection. We should strengthen targeted monitoring, protect susceptible populations, minimize hospitalization days, establish family wards, extend medical services to the community, reduce unnecessary hospitalization time and frequency, actively treat primary underlying diseases, and play the role of clinical pharmacists, standardize the use of antibacterial drugs to avoid unnecessary invasive operations, thereby reducing the incidence of nosocomial infections in geriatric department.