Abstract:
OBJECTIVE To investigate the clinical distribution and drug resistance of common Enterobacteriaceae bacteria in hospitals from 2013 to 2017, and to provide the theoretical basis for guiding the rational use of antibiotics in clinic and for making the prevention and control measures for nosocomial infections.
METHODS The department distribution and drug resistance of 8 466 strains of Enterobacteriaceae isolated from the people’s Hospital of Ningxia Hui Autonomous region from 2013 to 2017 were analyzed retrospectively, and the strains were identified.
RESULTS A total of 8 466 strains of Enterobacteriaceae were isolated from 2013 to 2017, including 4106 strains of
Escherichia coli（48.50%）, 3 129 strains of
Klebsiella pneumoniae（36.96%） and 723 strains of Enterobacter cloacae（8.54%）. The main specimens were respiratory tract and urinary tract. The resistance rate of
E. coli to imipenem was 2.24%, to piperacillin was 81.73%; the resistance rate of
K. pneumoniae to meropenem was 5.15%, to piperacillin was 25.83%; the resistance rate of
E. cloacae to meropenem was 5.53%, to cefazolin, cefuroxime, cefoxitin and amoxicillin/clavulanic acid was all higher than 95%.
CONCLUTION The Enterobacteriaceae bacteria are mainly isolated from the departments with high intubation frequency, and have resistances to different antibacterial drugs. Clinically, in the treatment of Enterobacteriaceae bacterial infection, carbapenem should be used cautiously according to the results of drug resistance phenotype and drug sensitivity test, and strictly implementing disinfection and isolation measurements to avoid cross-infection.
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