Abstract: OBJECTIVE To explore the species of pathogens isolated from the intensive care unit（ICU） patients with stroke-associated pneumonia（SAP） and analyze the influencing factors for multidrug-resistant organisms（MDROs） infections. METHODS A total of 160 patients with SAP who were hospitalized in the ICUs of Affiliated Hospital of Southwest Medical University from Mar 2015 to Sep 2018 were recruited as the study objects, the clinical data of the patients were retrospectively analyzed, the etiological characteristics of the infections were observed, and the univariate analysis and multivariate logistic regression analysis were performed for the influencing factors for the MDROs infections. RESULTS Of the 160 patients with SAP, 112 had MDROs infections.Totally 154 strains of MDROs were isolated, 105（68.18%） of which were gram-negative bacteria, 39（25.32%） were gram-positive bacteria; Pseudomonas aeruginosa, Acinetobacter baumannii and Klebsiella pneumoniae were the predominant species of the gram-negative bacteria; Staphylococcus aureus and Staphylococcus haemolyticus were dominant among the gram-positive bacteria.The gram-negative bacteria were resistant to most of the antibiotics and were highly susceptible to imipenem and tobramycin; the gram-positive bacteria were highly susceptible to moxifloxacin, vancomycin and teicoplanin.Late-onset SAP, complication with diabetes mellitus, sleepiness, endotracheal intubation, urinary catheter, gastric tube, prophylactic use of antibiotics, long-term mechanical ventilation and length of ICU stay were the influencing factors for the MDROs infections. CONCLUSION The incidence of MDROs infections is high among the ICU patients with SAP, and the strains are highly drug-resistant.The invasive procedures, high grade of disturbance of consciousness, diabetes mellitus and long length of ICU stay may increase the risk of MDROs infections.