Abstract: OBJECTIVE To explore the antibacterial activity of avibactam（AVI） combined with ceftazidime（CAZ） and aztreonam（ATM） against carbapenem-resistant Enterobacteriaceae（CRE）. METHODS A total of 143 strains of CRE were isolated from The First Affiliated Hospital of Da Lian Medical University from 2015 to 2018, the minimal inhibitory concentrations（MICs） of ceftazidime-avibactam（CAZ-AVI） and aztreonam-avibactam（ATM-AVI） were determined by using micro broth dilution method, and the extended-spectrum beta-lactamases-（ESBLs）, AmpC-and carbapenemase-related resistance genes were detected by means of PCR. RESULTS Among the 143 strains of CRE, the MIC₅₀ of CAZ-AVI was 8/4 μg/ml, 128 times low as that of CAZ, while the MIC₉₀ did not change.The MIC₅₀ of ATM-AVI was 1/4 μg/ml, 512 times low as that of ATM; the MIC₉₀ of ATM-AVI was 4/4 μg/ml,256 times low as that of ATM.As for the KPC-producing CRE strains, the MIC₅₀ of CAZ-AVI was 2/4 μg/ml, 512 times low as that of CAZ; the MIC₉₀ of CAZ-AVI was 8/4 μg/ml, 256 times low as that of CAZ.The MIC₅₀ of ATM-AVI was 1/4 μg/ml, 512 times low at that of ATM; the MIC₉₀ of ATM-AVI was 4/4 μg/ml, 256 times low as that of ATM.As for the NDM-producing CRE strains, the MIC₅₀ of CAZ-AVI was 1024/4 μg/ml, the MIC₉₀ 2048/4 μg/ml; the MIC₅₀ and MIC₉₀ of CAZ did not change as compared with CAZ-AVI.The MIC₅₀ of ATM-AVI was 0.5/4 μg/ml, 1 024 times low as that of ATM; the MIC₉₀ of ATM-AVI was 2/4 μg/ml, 512 times low as that of ATM. CONCLUSION CAZ-AVI can achieve remarkable antibacterial effect on the KPC-producing CRE strains but does not have inhibitory effect on the NDM-producing CRE strains.ATM-AVI has favorable antibacterial effect on both the KPC-and NDM-producing CRE strains.