Abstract: OBJECTIVE To investigate the expression of stimulator of interferon genes（STING） in the patients with chronic hepatitis B（CHB） and explore the its relationship with the hepatitis B virus（HBV） DNA load and liver histopathology. METHODS A total of 108 patients with CHB（the CHB group） and 60 people who volunteered for physical examination（the control group） were recruited as the study objects.The expression of STING mRNA and HBV DNA load were detected by using real-time fluorescence quantitative PCR, the levels of interferon-α（IFN-α） and interferon-β（IFN-β） were determined with the use of enzyme linked immunosorbent assay, the liver inflammation and fibrosis were graded for the CHB patients based on the results of liver biopsy and pathological grading criteria, and the relationship between the above indexes was observed. RESULTS The levels of STING mRNA, INF-α and INF-β of the CHB group were respectively（8.25±1.08）,（38.46±3.04）IU/ml and（35.17±2.86）IU/ml, significantly lower than those of the control group（P＜0.05）.The patients of the CHB group were divided into four groups according to the HBV DNA load, and there was significant difference in the serum STING mRNA among the four groups（F=26.492,P＜0.001）.There was significant difference in the expression of STING mRNA among the patients with different grades of liver inflammation and fibrosis in the CHB group（P＜0.05）.Pearson analysis showed that STING mRNA was positively correlated with INF-α and INF-β（P＜0.05）. CONCLUSION The STING shows a low expression in the CHB patients, the IFN-α/β is remarkably declined, which is associated with the HBV DNA load, the degree of inflammation and fibrosis in liver tissues.