Abstract: OBJECTIVE To explore the clinical effect of antibiotics combined with immunoglobulin on treatment of intermediate and advanced liver disease patients complicated with infection. METHODS A total of 200 intermediate and advanced liver disease patients complicated with infection who were treated in the First Affiliated Hospital, Xinxiang Medical College from Oct 2013 to Oct 2016 were enrolled in the study and randomly divided into the control group and the observation group, with 100 cases in each group.The control group was treated with hepatic conservation therapy, hepatic protection therapy combined with third generation cephalosporin cefotaxime sodium, while the observation group was given additional immunoglobulin on basis of the treatment of the control group.The curative effects were observed based on the Child-Pugh score stratification（divided into Child-Pugh less than 10 points and 10-15 points） after the treatment for 2 weeks, and the levels of inflammatory indexes and T lymphocyte subsets were analyzed. RESULTS There was no significant difference in the effective rate of clinical treatment of the patients with Child-Pugh less than 10 points between the two groups.Among the patients with Child-Pugh ranging between 10 and 15 points, the effective rate of clinical treatment of the observation group was 83.3%, significantly higher than 67.7% of the control group（P＜0.05）.The levels of inflammatory indexes CRP, PCT and IL-6 of the two groups of patients were significantly lower after the treatment than before the treatment（P＜0.05）, the levels of CRP, PCT and IL-6 of the patients with Child-Pugh ranging between 10 and 15 points were respectively（7.15±1.52）mg/L,（0.43±0.32）μg/L and（68.30±1.60）pg/ml in the observation group, significantly lower than those in the control group（P＜0.05）.The levels of T lymphocyte subsets CD₄⁺ and CD₄⁺/CD₈⁺ of the two groups of patients were significantly reduced after the treatment, while the levels of CD₈⁺ and Treg were significantly elevated, as compared with those before the treatment（P＜0.05）. CONCLUSION As for the liver disease patients with Child-Pugh less than 10 points, the antibiotics combined with immunoglobulin has little impact on the effective rate of clinical treatment of infection and inflammatory indexes as compared with the single antibiotic treatment, but it can boost the immune function.As for the liver disease patients with Child-Pugh ranging between 10 and 15 points, the antibiotics combined with immunoglobulin can not only raise the effective rate of treatment of infection, effectively inhibit the inflammatory indexes but also boost the immune function so as to improve the prognosis of the patients.