Abstract: OBJECTIVE To explore the application of continuous noninvasive hemodynamic monitoring combined with norepinephrine in treatment of elderly patients with septic shock. METHODS A total of 38 elderly patients with septic shock who were treated in the First People′s Hospital of Zunyi from Mar 2016 to Sep 2017 were enrolled in the study, all of the patients were treated with the norepinephrine combined with continuous noninvasive hemodynamic monitoring.The level of perfusion and improvement of oxygen metabolism of the patients were observed before the treatment and after the treatment for 6 and 12 hours, and the effects of the continuous noninvasive hemodynamic monitoring combined with norepinephrine on the level of perfusion, oxygen metabolism and hemodynamics were observed. RESULTS The heart rate（HR） of the patients was lower after the treatment than before the treatment; the mean arterial pressure（MAP）, cardiac output（CO） and cardiac index（CI） of the patients were higher after the treatment than before the treatment.With the extension of time, the HR of the patients was declined, while the MAP, CO and CI were elevated, and there were significant differences in the related indexes after the treatment for 12 hours and after the treatment for 6 hours（P＜0.05）.The oxygen delivery（DO₂） and systemic central venous oxygen saturation（ScvO₂） of the patients were significantly higher after the treatment than before the treatment; while the lactate（Lac） level of the patients was significantly lower after the treatment than before the treatment, the clearance rate of Lac was significantly higher after the treatment for 12 hours than after the treatment for 6 hours（P＜0.05）.The average length of hospital stay of the patients was（14.61±6.05） days.There were 1 case of cerebral edema, 1 case of pulmonary edema and 1 case of heart failure during the treatment, the incidence of complications was 7.89%, and the incidence of multiple organ dysfunction syndrome（MODS） was 23.68%（9/38）. CONCLUSION As used for the treatment of the elderly patients with septic shock, the continuous noninvasive hemodynamic monitoring combined with norepinephrine may effectively raise the perfusion level and improve the oxygen metabolism as well as the dynamics.