Abstract: Pseudomonas aeruginosa (PA) is a non-fermenting gram-negative bacillus that is opportunistically pathogenic and is one of the most common pathogens causing chronic and infections nosocomial infections. The resistance of P.aeruginosa to antibiotics includes endogenous,acquired and adaptive resistance. Due to the increase of clinical multidrug-resistant P.aeruginosa (MDR-PA) strains,infection has become a huge challenge for clinical treatment. Therefore, the development of new antibiotics and the search for antibiotic substitutes with antibacterial effects are ideal choice for clinical treatment of P.aeruginosa infection. This article will review the development of new antibiotics and new therapies so as to facilitate the clinical treatment of P.aeruginosa infection.