Abstract: OBJECTIVE To explore the predictive value of urine N-acetyl-beta-D-glucusamidase（NAG）, serum procalcitonin（PCT） and sequential organ failure assessment（SOFA） score for acute kidney injury（AKI） in sepsis patients. METHODS A retrospective analysis was performed on 79 sepsis patients, who were admitted to the department of critical care medicine, Nanyang Central Hospital from Dec. 2016 to Dec. 2018. According to presence or absence of AKI, they were divided into the AKI group（n=51） and non-AKI group（n=28）. The enzyme linked immunosorbent assay（ELISA） was applied to detect the serum PCT level. Logistic analysis was applied to analyze risk factors of AKI in sepsis patients. Pearson correlation analysis was applied to analyze the correlation between urine NAG, serum PCT and SOFA score and KDICO staging in patients with sepsis and AKI. ROC analysis was applied to analyze predictive value of urine NAG, serum PCT and SOFA score for AKI in sepsis patients. The area under the curve（AUC） indicated the predictive value. RESULTS Urine NAG, SOFA score and PCT were independent factors influencing AKI in sepsis patients（P＜0.05）. Urine NAG, serum PCT and SOFA score were positively correlated with KDICO grading in AKI patients（P＜0.001）. AUCs of urine NAG, serum PCT, SOFA score and their combined detection for predicting AKI in sepsis patients were 0.819, 0.748, 0.721 and 0.914, respectively. CONCLUSION The predictive value of urine NAG was the highest for AKI injury in sepsis patients, which combined with serum PCT and SOFA score can further improve the predictive efficiency.