Abstract: OBJECTIVE To observe the effects of Xueduqing combined with conventional western medicine on brain injury factors and infectious inflammatory markers in patients with sepsis-associated encephalopathy（SAE）. METHODS A total of 72 SAE patients in Shengli Oilfield Central Hospital from May 2016 to Aug. 2019 were recruited and divided into the observation group（n=36） and control group（n=36） by simple randomization. The control group was treated with conventional western medicine, and the observation group was treated with Xueduqing on the basis of the control group. All patients were treated for 7 days. Levels of severity score（APACHEⅡ）, coma score（GCS）, serum brain injury factors including S100β, neuron-specific enolase（NSE）, markers of infectious inflammation such as procalcitonin（PCT）, C-reactive protein（CRP）, white blood cell count（WBC） and T lymphocyte subsets（CD₈⁺, CD₄⁺, CD₄⁺/CD₈⁺） before and 7 days after the treatment in the two groups were compared, and the 28-day mortality rate in the two groups was calculated. RESULTS After the treatment for 7 days, the total effective rate was 91.67%,which was significantly higher than that in the control group（72.22%）（P＜0.05）. The APACHEⅡ score and serum levels of S100β, NSE, PCT, CRP, WBC and CD₈⁺ in two groups decreased after 7 days of treatment, and the observation group was significantly lower than that in the control group; GCS score and serum CD₄⁺, CD₄⁺/CD₈⁺ levels were significantly higher after the treatment than before the treatment, and the observation group was significantly higher than that in the control group（P＜0.05）. The 28-day mortality rate in the observation group was 19.44%, which was significantly lower than that in the control group of 41.67%（P＜0.05）. CONCLUSION The application of Xueduqing combined with conventional western medicine in the treatment of SAE patients can improve the curative effect and alleviate the degree of illness and coma by reducing the expression of brain injury factors and infectious inflammatory markers, so as to improve immune function and reduce mortality.