Abstract: OBJECTIVE To explore the effect of Chinese medicine on the prognosis and serum levels of PCT and CRP in patients with severe pulmonary infection. METHODS From Jun. 2017 to Jun. 2019, 100 patients with severe pulmonary infection in Lishui Second People’s Hospital of Zhejiang Province were divided into the observation group（n=50） and control group（n=50）. The patients in the control group were treated with conventional therapy, whereas the patients in the observation group were treated with traditional Chinese medicine. The clinical efficacy between two groups was evaluated; and the mechanical ventilation time, clinical symptoms improvement time and hospitalization time between the two groups were recorded; the serum PCT and CRP levels between the two groups before and after treatment were compared. RESULTS The total clinical effective rate in the observation group（90.00%） was significantly higher than that in the control group（72.00%）. The mechanical ventilation time, lung rale disappearance time, body temperature recovery time, blood picture recovery time and hospitalization time in the observation group were significantly shorter than that in the control group（P＜0.05）. After the treatment, the levels of PCT and CRP in the observation group were significantly lower than that in the control group（P＜0.05）. CONCLUSION Assistant treatment of traditional Chinese medicine in patients with severe pulmonary infection can effectively reduce the level of inflammation and improve the prognosis of disease in patients.