Abstract: OBJECTIVE To understand the changes of clinical distribution and drug resistance rates of the high mucus phenotype Klebsiella pneumoniae strains so as to provide guidance for clinical practice. METHODS A total of 617 clinical isolates of high mucus phenotype K. pneumoniae were collected from Jan 2011 to Dec 2018.Cephalosporinase（AmpC） was detected by three-dimensional test, extended-spectrum beta-Lactamases（ESBLs） were detected by two-disk synergistic diffusion method, the bacteriological identification was carried out by using Phoenix-100 automatic bacterial identification system, and the minimum inhibitory concentration（MIC） was determined by means of drug susceptibility system, the results were interpreted based on the standards of Clinical and Laboratory Standards Institute（CLSI）, and the statistical analysis was performed. RESULTS The high mucus phenotype K. pneumoniae strains accounted for 12.17% among the K. pneumoniae strains and 2.76% among Enterobacteriaceae strains.The drug resistance rates to cefazolin, ampicillin, ampicillin-sulbactam, ceftriaxone and amoxicillin-clavulanic acid were no less than 20%, while the drug resistance rates to other antibiotics were less than 10%; the drug resistance rates to gentamicin, ciprofloxacin, amikacin, oxacillin, ampicillin, levofloxacin, ampicillin-sulbactam, cefuroxime, piperacillin-tazobactam, cefoperazone, cefepime, ceftazidime, tobramycin, aztreonam and minocycline significantly increased year by year（P＜0.05）.The detection rates of ESBLs and AmpC also significantly increased year by year（P＜0.05）. CONCLUSION The detection rates of ESBLs and AmpC as well as drug resistance rates of the high mucus phenotype K. pneumoniae strains are increased year by year, and it is necessary to pay great attention to the monitoring and control of the enzyme-producing strains.