Abstract: OBJECTIVE COVID-19 is characterized by fast spread, wide range of spread and high mortality rate, which leads to the increase of difficulty in the prevention and control and risk of the medical treatment. The ordinary hospital management model no longer meets the requirements for the progression of the epidemic, the medical institutions are facing brand new challenges in medical treatment, prevention and control. The hospital is the place for treatment and also the source of nosocomial cross infection, it is the top priority for the medical institutions to orderly conduct the treatment, eliminate hidden danger of the epidemic and reduce the risk of nosocomial infection. METHODS As the hospital designated for treatment of the patients with COVID-19 in Beijing and the troops stationed in Beijing, The Fifth Medical Center of Chinese PLA General Hospital possesses the practical experience in combating with SARS, influenza A and Ebola virus disease and carries out the work by focusing on the reception task based on early warning response, establishment of coping treatment agencies, mobilization of group training, management of fever clinic and isolation sections, general (outpatient) wards, patients and front-line medical staff as well as disposal of medical waste. RESULTS The medical treatment was carried out in a orderly manner, and the scientific rules and regulations for prevention and control of the epidemic were implemented. CONCLUSION The implementation of the above strategies and measures enables the timely reception and scientific treatment and achieves a phased objective in prevention of nosocomial cross infection, which lays a solid foundation for realizing the 'zero infection of the staff' and 'zero cross infection of patients'.