Abstract: OBJECTIVE To analyze etiological features of children with infectious diarrhea in Zunyi and to evaluate the predictive value of serum C-reactive protein（CRP）, interleukin-17（IL-17） and soluble interleukin-2 R（sIL-2 R） in infection. METHODS A total of 347 children who were confirmed with acute infectious diarrhea in the pediatrics outpatient of Zunyi first people’s Hospital from Jan. 2019 to Dec. 2019 were enrolled as the infection group, and 100 children without infectious diarrhea who were admitted to the unit in the same period were enrolled as the non-infection group. Fresh stool samples from children were collected aseptically for pathogens isolation and identification and rotavirus（RV） antigen examination. The drug sensitivity tests were performed on the isolated strains. The levels of serum CPR, IL-17 and sIL-2 R were detected by enzyme linked immunosorbent assay（ELISA）. Their predictive value in infectious diarrhea was analyzed by ROC curves. RESULTS Among 347 children with infectious diarrhea, detectable rates of pathogens and RV were 23.92% and 15.56%, respectively. The drug resistance rates of main isolated pathogens such as Salmonella, Shigella and Escherichia coli to ampicillin and piperacillin were high, but pathogens were most sensitive to imipenem. The drug resistance rates of Staphylococcus aureus to penicillin G, ampicillin and piperacillin were high, with the lowest drug resistance rate to vancomycin. The levels of serum CRP, IL-17 and sIL-2 R of the infection group were significantly higher than those of the non-infection group（P＜0.05）. The areas under ROC curves（AUCs） of serum CRP, IL-17 and sIL-2 R in the diagnosis of infectious diarrhea were 0.735, 0.720 and 0.752. And AUC of their combined detection was 0.867. CONCLUSION The main pathogens in children with infectious diarrhea included RV, Salmonella, Shigella, etc. Clinically, combination detection of serum CRP, IL-17 and sIL-2 R can predict occurrence of infectious diarrhea.