Abstract: OBJECTIVE To explore the values of D-dimer, hematocrit（Hct）/albumin（Alb）, and soluble triggering receptor expressed on myeloid cells（sTREM-1） in diagnosis of infusion port chemotherapy-induced infection in breast cancer patients and identification of pathogens. METHODS From Jul 2018 to Jul 2020, totally 65 breast cancer patients with infusion port chemotherapy-induced infection who were treated in the Henan Provincial People’s Hospital were chosen as the infection group, and 65 breast cancer patients without infusion port chemotherapy-induced infection were chosen as the no infection group. The C-reactive protein（CRP）, white blood cell（WBC） counts, D-dimer, Hct/Alb and sTREM-1 were compared between the two groups, logistic regression analysis was performed for influencing factors for the infusion port chemotherapy-induced infection, the D-dimer, Hct/Alb and sTREM-1 were compared among the patients with different pathogens infections, and the efficiencies in diagnosis of infection and identification of pathogens were analyzed by receiver operating characteristic（ROC） curve. RESULTS The CRP, WBC, D-dimer, Hct/Alb and sTREM-1 of the infection group were significantly higher than those of the non-infection group（P＜0.05）. The D-dimer, Hct/Alb and sTREM-1 were positively correlated with the CRP and WBC（P＜0.05）. The AUCs of the D-dimer, Hct/Alb and sTREM-1 were high in diagnosis of the infusion port chemotherapy-induced infection, and the AUC of the joint detection of above indexes was 0.900, significantly higher than that of any single index. D-dimer :G^-＞G⁺＞fungi, the Hct/Alb of the patients with fungal infection was significantly higher than that of the patients with G⁺ and G^- infections（P＜0.05）. D-dimer could identify the G^-, G⁺ and fungi, and the area under curve（AUC） was the largest in identification of G^-（0.827）; Hct/Alb could identify bacteria and fungi, with the AUC 0.826. CONCLUSION D-dimer, Hct/Alb and sTREM-1 show high expression in the breast cancer patients with infusion port chemotherapy-induced infection. The joint detection of the indexes may raise the diagnostic efficiency, D-dimer and Hct/Alb can be used for identification of different pathogens and provide guidance for taking targeted treatment and intervention measures.