Abstract: OBJECTIVE To investigate the risk factors for Staphylococcus aureus infection in patients with rheumatic immune disease and analyze the drug resistance. METHODS A total of 63 rheumatic immune disease patients who were complicated with S.aureus infection and treated in the Affiliated Hospital of Qinghai University from Jun 2015 to Aug 2020 were assigned as the infection group, and 126 rheumatic immune disease patients who were not complicated with infection were randomly chosen as the non-infection group. The secretions specimens were collected from the infection sites, pathogens were isolated, and drug susceptibility testing was performed. The age, diabetes mellitus, invasive procedures, use of immunosuppressors, albumin, C-reactive protein（CRP） and erythrocyte sedimentation rate（ESR） of the patients were recorded. The influencing factors for S.aureus infection were analyzed by dichotomy Logistic regression model, and the predictive efficiency of the model was detected by means of receiver operating characteristic（ROC） curve. RESULTS Complication with diabetes mellitus（OR=2.277,P=0.025）, invasive procedures（OR=3.080,P=0.006）, use of immunosuppressors（OR=2.401,P=0.019） and length of hospital stay no less than 14 days（OR=2.184,P=0.046） were the independent risk factors for the S.aureus infection. Among the patients with S.aureus infection, 41.27% had upper respiratory tract infection; the drug resistance rates of the methicillin-resistant S.aureus（MRSA） strains to oxacillin, levofloxacin and ciprofloxacin were significantly higher than those of the methicillin-sensitive S.aureus（MSSA） strains（P＜0.05）. CONCLUSION Complication with diabetes mellitus, invasive procedures, use of immunosuppressors and length of hospital stay no less than 14 days are the risk factors for the S.aureus infection in the patients with rheumatic immune disease. Teicoplanin and vancomycin can be used for clinical treatment.