Abstract: OBJECTIVE To explore the values of blood free β human chorionic gonadotropin（Free-β-HCG） and coagulation function indexes in prediction of adverse pregnancy outcomes in the pregnant women with human cytomegalovirus（HCMV） infection. METHODS A total of 62 pregnant women with HCMV infection who were treated in the Affiliated Hospital of Chengde Medical University from Oct 2017 to Dec 2019 were assigned as the infection group, meanwhile, 62 healthy pregnant women were set as the control group. The baseline data and levels of blood coagulation indexes fibrinogen（FIB）, activated partial thromboplastin time（APTT）, international normalized ratio（INR） and blood Free-β-HCG were observed and compared between the two groups and among the pregnant women with different pregnancy outcomes in the infection group. Receiver operating characteristic（ROC） curve was drawn to explore the values of the indexes in prediction of adverse pregnancy outcomes of the pregnant women with HCMV infection. RESULTS The blood FIB level of the infection group was significantly higher than that of the control group, and the blood APTT, INR and Free-β-HCG level of the infection group were significantly lower than those of the control group（P＜0.05）. There were no significant differences in the age, progestational body mass, gestational weeks, gravidity and type of pregnant woman among the pregnant women with different pregnancy outcomes in the infection group. The blood FIB level of the pregnant women with adverse pregnancy outcomes was significantly higher than that of the pregnant women without adverse pregnancy outcomes, while the blood APTT, INR and Free-β-HCG level of the pregnant women with adverse pregnancy outcomes were significantly lower than those of the pregnant women without adverse pregnancy outcomes（P＜0.05）. ROC curve showed that both single and joint detection of the indexes had large area under curve（AUC）, with the joint detection the highest（0.893）. CONCLUSION The pregnant women with HCMV infection present with abnormal changes of blood coagulation function and blood Free-β-HCG level, which are associated with the adverse pregnancy outcomes. The joint detection of the indexes may raise the value in prediction of HCMV infection and facilitate the early intervention.