Abstract:
OBJECTIVE To explore the dynamic changes and significance of peripheral blood T lymphocyte subsets and CD
4+/CD
8+ ratio in patients with large hemispheric infarction(LHI) and pulmonary infection(PI).
METHODS A retrospective analysis was performed on the data of 100 LHI patients complicated with PI who were admitted to hospital between Mar 2011 and May 2017. Peripheral blood T lymphocyte subsets were detected on the day of admission, 3 d and 7 d after admission. The Glasgow Coma Scale(GCS), the clinical pulmonary infection score(CPIS) and the modified Rankin scale on Day 28 were used to assess the severity of LHI and PI and prognosis in patients. Based on the evaluation results, patients were divided into groups and dynamic changes of peripheral blood T lymphocyte subsets and CD
4+/CD
8+ ratio, and their clinical significance in patients with different severity of disease and different prognosis were analyzed.
RESULTS The CD
3+ and CD
4+ T-cells and CD
4+/CD
8+ ratio in patients with LHI in the severe group, moderate group and mild group increased in order, while CD
8+ in the three groups decreased sequentially(
P<0.05). CD
3+ and CD
4+ T-cells and CD
4+/CD
8+ ratio in the good prognosis group were significantly higher than those in the poor prognosis group, and the levels of CD
8+ T-cells was significantly lower than that in the poor prognosis group(
P<0.05). ROC curve showed that the area under the curve(AUC) values of CD
3+, CD
8+ and CD
4+ T-cells and CD
4+/CD
8+ ratio for predicting poor prognosis were 0.855, 0.871, 0.729, and 0.557, respectively.
CONCLUSION Dynamic changes of peripheral blood T lymphocyte subsets and CD
4+/CD
8+ ratio in patients with LHI and PI are related to the degree of patient’s severity, which can be used to predict the prognosis.