Abstract: OBJECTIVE To investigate the relationship between serum miRNA profile expression, wound repair factors and immune function in type 2 diabetes patients with diabetic foot infection.METHODS 80 type 2 diabetes patients with diabetic foot infection admitted to the Department of Endocrinology in First Hospital of Jilin University from Jan. 2020 to Dec. 2020 were selected as the study group, and 60 type 2 diabetes patients without any infection treated in the Department of Endocrinology of the hospital during the same period were selected as control group. After extracting serum RNA by Trizol method, real-time quantitive polymerase chain reaction（RT-PCR） was used to detect the levels of miR-21, miR-132 and miR-155; enzyme-linked immunosorbent assay was used to detect the levels of platelet-derived growth factor BB（PDGF-BB） and basic fibroblast growth factor（bFGF） in wound secretions, and flow cytometry was used to detect peripheral blood CD₄⁺, CD₈⁺, NK and monocyte levels.RESULTS The levels of PDGF-BB and bFGF in the study group were significantly higher than those in the control group, while the levels of CD₄⁺/CD₈⁺, NK and monocytes were significantly lower than those in the control group（P＜0.05）. The relative expression of miR-21 and miR-132 in Wanger grade 3-4 patients were significantly lower than those in Wanger grade 1 to 2 patients, the relative expression of miR-155 was significantly higher than Wanger grade 1 to 2 patients（P＜0.05）. The PDGF-BB and bFGF levels of Wanger 3-4 patients were significantly higher than those of Wanger 1-2 patients, but the CD₄⁺/CD₈⁺, NK and monocyte levels were significantly lower than those of Wanger grade 1-2 patients（P＜0.05）.CONCLUSION The miR-21, miR-132 and miR-155 had certain correlation with the disease grading, wound repair factors and cellular immune levels of type 2 diabetes patients with diabetic foot infection, which could be used as a basis for clinical judgment. The value of their targeted therapy needs follow up research.