Abstract: OBJECTIVE To explore the infection sites, isolation rates and drug resistance of carbapenem-resistant Pseudomonas aeruginosa causing infection in intensive care unit（ICU） and common wards.METHODS The clinical data and microbiological test information of 239 836 patients who were hospitalized in the First Affiliated Hospital of Suzhou University from Jan 2016 to Dec 2019 were retrospectively investigated, 50 case-times of ICU patients and 42 case-times of patients in common wards were diagnosed with carbapenem-resistant P.aeruginosa infection. The characteristics of carbapenem-resistant P.aeruginosa infection and drug resistance were observed.RESULTS Totally 92 case-times of patients were diagnosed with carbapenem-resistant P.aeruginosa infection in the two groups. The sputum was the major specimen resource, and the patients with lower respiratory tract infection were dominant. The detection rate of carbapenem-resistant P.aeruginosa infection was higher among the ICU patients（31.85%） than among the patients of common wards（22.18%）. The drug resistance rates of the carbapenem-resistant P.aeruginosa to tobramycin, gentamicin and amikacin were the lowest, ranging between 0 and 16.13%. The drug resistance rates of the strains isolated from the ICU patients to ticarcillin-clavulanic acid, aztreonam, levofloxacin and moxifloxacin ranged between 58.06% and 80.65%; the drug resistance rates of the strains isolated from the patients of common wards to most of the commonly used antibiotics were less than 25%. The drug resistance rates of the strains isolated from the ICU patients to piperacillin, piperacillin-tazobactam, ticarcillin-clavulanic acid, cefepime, cefoperazone-sulbactam and quinolones were significantly higher than those of the strains isolated from the patients of common wards（P＜0.05）.CONCLUSION The patients with lower respiratory tract infection are dominant among the patients with carbapenem-resistant P.aeruginosa infection in the ICUs and common wards. The isolation rate of carbapenem-resistant P.aeruginosa strains is relatively high in the ICUs, and the strains vary in the drug resistance. It is necessary to strengthen the surveillance of carbapenem-resistant P.aeruginosa infection and reasonably use antibiotics so as to effectively control the infection and prevent the drug resistance of the strains from rapid increase and transmission.