Abstract: OBJECTIVE To explore the clinical characteristics of acquired immune deficiency syndrome（AIDS） patients complicated with cryptococcal meningitis and influencing factors for prognosis. METHODS The clinical data of 90 AIDS patients complicated with cryptococcal meningitis who were hospitalized in Zhongnan Hospital of Wuhan University from Jan 2012 to Jul 2018 were retrospectively analyzed, and the clinical characteristics and influencing factors for prognosis were observed. RESULTS Among the most common clinical manifestations of the AIDS patients complicated with cryptococcal meningitis, 90.00%（81/90） had fever, 83.33%（75/90） had dizziness or headache, and 58.89%（53/90） had nausea and vomiting. The positive rates of cryptococcus antigen, ink staining and culture of the cerebrospinal fluid were 92.59%（50/54）, 78.89%（71/90） and 51.11%（46/90）, respectively. The total mortality rate was 25.56%（23/90） after antifungal treatment. Univariate analysis of the influencing factors for 12-week prognosis of the AIDS patients complicated with cryptococcal meningitis showed that the number of the patients with had antiretroviral therapy（cART）, disturbance of consciousness, seizures, rigid neck and low CD₄⁺ T cell counts was significantly larger in the death group than in the survival group, the incidence rate of systemic disseminated cryptococcal infection of the death group was significantly higher than that of the survival group（P＜0.05）. Multivariate logistic regression analysis indicated that disturbance of consciousness, seizures and rigid neck were the risk factors for the 12-week prognosis of the patients. CONCLUSION The AIDS patients with cryptococcal meningitis are usually complicated with disseminated infection. The disturbance of consciousness, seizures and rigid neck are the risk factors for poor prognosis of the AIDS patients complicated with cryptococcal meningitis. It is necessary to carry out the routine cryptococcus antigen test for the patients with CD₄⁺ T cell counts less than 100/μl before cART so as to make a early diagnosis and treatment and further reduce the mortality rate.