Abstract: OBJECTIVE To investigate the influencing factors of cerebral infarction complicated with pulmonary infection, and the relationship between glucose metabolism, red blood cell distribution width（RDW） and severity of infection. METHODS A total of 386 patients with acute cerebral infarction treated in Hengshui People's Hospital from October 2017 to December 2019 were selected. The influencing factors of pulmonary infection in patients with acute cerebral infarction were analyzed. The levels of C reactive protein（CRP）, procalcitonin（PCT）, fasting blood glucose（FBG）, RDW of patients with different pneumonia severity index（PSI） in the infection group were analyzed. RESULTS 108 cases of 386 patients with acute cerebral infarction complicated with pulmonary infection, the infection rate was 27.98%. Previous history of pulmonary diseases, abnormal glucose metabolism, invasion operation, hospitalization time and RDW level at admission were the influencing factors of pulmonary infection（P＜0.05）. There were significant differences in the levels of CRP, PCT, FBG and RDW among patients with different severity of lung infections（P＜0.05）, among which the levels of those indicators of patients in the high-risk group were significantly higher than those of patients in the intermediate-risk group, and significantly higher than those of patients in the lower-risk group.（P＜0.05）. CONCLUSION There were many influencing factors of acute cerebral infarction patients with complicated with pulmonary infection. The levels of FBG and RDW were closely related to the severity and prognosis of infection. Clinically, the above indexes should be detected in time and actively responded to improve their prognosis.