Abstract: OBJECTIVE To explore the association between Melanocortin-1 receptor（MC1 R） gene polymorphism and the susceptibility to post-traumatic sepsis. METHODS The 70 patients with post-traumatic sepsis admitted to the emergency department of Baoding First General Hospital from Jan 2018 to Jan 2021 were selected as the study group, and 70 patients without post-traumatic sepsis during the same period were continuously collected as the control group. Peripheral venous blood of patients were collected, and specific primers of MC1 R gene rs885479（c.488 G＞A） site were designed. The target fragment of MC1 R gene was amplified by polymerase chain amplification reaction（PCR）. The amplified products were recovered and sent to the company for sequencing. The distribution of MC1 R gene rs885479 in the study group, the control group, and the study group with different prognosis（28-day mortality） was compared. RESULTS The frequency of AA genotype and A allele at rs885479 locus of MC1 R gene in significantly higher than that of the control group, while the frequency of GG genotype and G allele was significantly lower than that of the control group. The results of multivariate logistic analysis showed that carrying with AA genotype and A allele of MC1 R gene at rs885479 was risk factors for sepsis after trauma, and genotype carrying GG was a protective factor（P＜0.05）. The frequency of AA genotype and A allele at MC1 R gene at rs885479 in the death group was significantly higher than that of the survival group, and the frequency of GG genotype and G allele was significantly lower than that of the control group, and the difference was statistically significant（P＜0.05）. CONCLUSION The AA genotype of MC1 R gene at rs885479 locus significantly increased the incidence of post-traumatic sepsis in the population in this area, which was related to the clinical prognosis of patients.