Abstract: OBJECTIVE To establish the risk prediction model for postoperative abdominal infection in the patients with colorectal cancer and analyze the expressions of Hippo signaling pathway genes. METHODS The clinical data were retrospectively collected from 442 colorectal cancer patients who were treated in Baotou Tumor Hospital from Jan 2018 to Oct 2019. The patients were divided into the infection group with 55 cases and the no infection group with 388 cases according to the status of postoperative abdominal infection. The clinical data were collected from the patients after the admission, the expression levels of Hippo signaling pathway genes were detected. Multivariate logistic regression analysis was performed for the risk factors for the postoperative abdominal infection, the prediction model was established, and the predictive value of the model was analyzed by means of receiver operating characteristic (ROC) curve. RESULTS The result of multivariate logistic regression analysis showed that complication with diabetes mellitus, long operation duration and high levels of Yes-associated protein (Yap) messenger ribonucleic acid (mRNA),transcriptional coactivator with PDZ-binding motif (taZ) mRNA and mammalian STE20-like protein kinase1 (mst1) mRNA were the independent risk factors for the postoperative abdominal infection in the colorectal cancer patients (P＜0.05). ROC curve analysis indicated that the area under curve (AUC) of the model established based on the above risk factors was 0.846 in prediction of the postoperative abdominal infection, with the sensitivity 80.00%, the specificity 76.29%. CONCLUSION The independent risk factors for the postoperative abdominal infection include the complication with diabetes mellitus, long operation duration and the high levels of Yap mRNA, taZ mRNA and mst1 mRNA. The value of the model established based on the risk factors is high in prediction of the postoperative abdominal infection in the colorectal cancer patients.