Abstract: OBJECTIVE To analyze the influencing factors for wound infection in the patients with poisonous snake bit and establish the logistic regression equation. METHODS The clinical data were retrospectively collected from 409 patients with poisonous snake bite who were treated in Dazhou Central Hospital from Mar 2018 to Oct 2022, the patients were divided into the infection group with 68 cases and the no infection group with 341 cases according to the status of wound infection. The influencing factors for the wound infection in the patients with poisonous snake bite were analyzed, the regression equation was established, and the predictive value of the regression equation was analyzed by means of receiver operating characteristic (ROC) curves. RESULTS Wound incision, Ⅱ degree or Ⅲ degree ulcer, and use of antivenin were independent risk factors for wound infection in the patients with poisonous snake bite; prophylactic use of antibiotics was the protective factor for wound infection(P＜0.05). The regression equation was established based on the result of multivariate analysis: Logit(P)=-3.552+wound incision×0.983+ulcer degree×1.192+use of antivenin×1.072-prophylactic use of antibiotics×0.846. The result of ROC curve analysis showed that when the Logit(P) was more than 12.83, the area under curve(AUC) was 0.916, with the sensitivity 85.29%, the specificity 82.40%. CONCLUSION The independent risk factors for the wound infection in the patients with poisonous snake bite include the wound incision, Ⅱ degree or Ⅲ degree ulcer and use of antivenin. The prophylactic use of antibiotics is the protective factor for the wound infection. The regression equation has high value in prediction of wound infection in the patients with poisonous snake bite.