Abstract: OBJECTIVE To investigate the distribution of pathogens isolated from the diabetic foot patients with ulcer infection, analyze the risk factors and establish the prediction model. METHODS A total of 42 diabetic foot patients who were complicated with ulcer infection and were treated in Xinxiang Central Hospital form Aug 2019 to Jun 2022 were assigned as the infection, and 60 patients who were not complicated with ulcer infection were chosen as the no infection group. The distribution of pathogens isolated form the diabetic foot patients with ulcer infection was observed. Multivariate logistic regression analysis was performed for the risk factors for the ulcer infection, the prediction model was established, and the predictive value of the model was analyzed by means of receiver operating characteristic (ROC) curve. RESULTS Totally 49 strains of pathogens were isolated from 42 diabetic foot patients complicated with ulcer infection. Escherichia coli, Pseudomonas aeruginosa, Staphylococcus epidermidis, Staphylococcus aureus and Candida albus were the predominant species of pathogens. Complication with diabetic large vascular disease, complication with osteomyelitis, antibiotic treatment course more than 14 days and combined use of no less than 2 types of antibiotics were the risk factors for the ulcer infection in the diabetic foot patients(P＜0.05). The area under curve (AUC) of the model established based on the risk factors was 0.850 in prediction of the ulcer infection in the diabetic foot patients, with the sensitivity 66.67%, the specificity 90.00%. CONCLUSION The major species of pathogens isolated from the diabetic foot patients with ulcer infection include E. coli, P. aeruginosa, S.epidermidis,S. aureus and C.albus. The major risk factors for the infection include diabetic large vascular disease, complication with osteomyelitis, course of antibiotic treatment more than 14 days and combined use of no less than 2 types of antibiotics.