Abstract: OBJECTIVE To observe the effects of quality control enhancement and continuous improvement management on quality of disinfection and sterilization and infection control in central sterile supply department. METHODS The routine management was carried out in central sterile supply department of Beijing Elderly Hospital from May 2020 to May 2021;the intensified quality control and continuous improvement management was carried out from Aug 2021 to Aug 2022. The disinfection and sterilization quality of 1 017 medical instruments and incidence of adverse events were statistically analyzed before and after the management measures were improved. 32 hospitalized patients were respectively included before and after the improvement. The incidence of surgical site infection and constituent ratios of pathogens causing the surgical site infections were statistically analyzed before and after the improvement. RESULTS The qualified rates of cleaning quality, disinfection and sterilization, packaging quality, recycling, acceptance, classification and assignment were higher after the improvement than before the improvement(P<0.05). The incidence rates of wet bag event, inconsistency between outer label and inner device, delayed recording, wrong date of sterile bag label, loss of device and indicator leakage were lower after the improvement than before the improvement (P<0.05). The total incidence rate of surgical site infection among the 32 patients matching with medical instruments was lower after the improvement than before the improvement(P<0.05). A total of 10 patients had surgical site infection during the study. Totally 16 strains of pathogens were isolated, Acinetobacter baumannii was the predominant species of gram-negative bacteria, and Staphylococcus aureus was dominant among the gram-positive bacteria. CONCLUSION The quality control enhancement and continuous improvement management can effectively improve the quality of disinfection and sterilization of medical instruments in the central sterile supply department and reduce the incidence of medical instrument-related adverse events as well as the incidence of surgical site infection.