Abstract: Carbapenem-resistant Enterobacteriaceae (CRE) has become a major threat to global public health and is characterized by rapid transmission and high mortality after infection. Hospital-acquired infection is one of the main routes of infection. The transmission and infection of CRE pose a serious threat to the health of patients. The prevention and management of CRE is an important part of controlling the transmission and infection of CRE. The risk factors for CRE infection and colonization, active screening strategies of CRE for patients and environment and multidisciplinary collaborative management model were reviewed in the article. The risk factors for CRE infection and colonization, active screening population, screening methods, screening time points and screening frequencies were summarized. The active screening scope, screening method, screening frequency, termination time point of active screening and development of multidisciplinary collaborative management mode were sorted out so as to understand the active screening strategies and latest progress of multidisciplinary collaborative prevention and control and provide theoretical support for clinical prevention and control of CRE.