Abstract: Cartilage, tendon and bone tissue injuries are common diseases for orthopedics and sport medicine. Platelet rich plasma (PRP) contains various types of high concentrations of growth factors and mediators. Centrifuged and concentrated PRP was injected into to injured sites, which may facilitate the self-healing. The treatment of bone, cartilage and other soft tissue injuries with PRP has become a research hotspot. PRP is supposed to be an effective supplement for prevention of postoperative infection, treatment of chronic wounds and prevention of implant-associated infection due to its containing with a large number of platelets, high concentrations of white blood cells and a variety of antimicrobial peptides. In combination with the latest issued PRP-related expert consensuses, the effect of PRP on treatment of the bone, cartilage and other soft tissue injuries was evaluated in the review article.