OBJECTIVE To analyze the impact of Root Cause Analysis (RCA) combined with the PDCA cycle management model on the rate of pathogenetic delivery before antimicrobials treatment in hospitalized patients.

METHODS 2, 454 cases of therapeutic use of antimicrobial drugs in a tertiary general hospital in Luoyang City, Henan Province, from April to June 2021 were selected as the control group, and the RCA method combined with the PDCA cycle management mode was adopted from Aug.1, 2021, and 2, 417 cases of therapeutic use of antimicrobial drugs from Apr.to June 2022 were selected as the intervention group, and the pathogenic delivery rate before antimicrobials treatment was compared between the two groups, including different classes of antimicrobial drugs, different pathogenetic items and various types of microorganisms and microscopic examination items.

RESULTS The rates of pre-treatment pathogenetic specimen delivery for antimicrobials, restricted antimicrobials, and special antimicrobials in the intervention group were 74.39%, 74.50%, and 89.04%, respectively, which were higher than those in the control group at (P < 0.001).In the nine clinical departments, except for gynecology, and the pathogenicity delivery rate before antimicrobials treatment in hospitalized patients in the remaining 8 departments was higher than that of the control group (P < 0.05).The delivery rate of all types of pathogenetic items and all types of microbial culture and microscopic examination items in the intervention group were higher than those in the control group (P < 0.05).

CONCLUSION The RCA method in combination with the PDCA cycle management model was effective in increasing the pathogenetic delivery rate before antimicrobials treatment in hospitalized patients.